Questions:
1. How many times have you killed Mom's Heart?
2. With which character(s) have you killed Satan in Sheol?
3. Have you beaten the Cathedral boss, and with which characters?
4. How quickly have you beaten Mom? (Your target time is 20 minutes)
Other tips:
1. It is only ever OK to take red-heart damage from enemies and spikes on floor 1
2. Do the challenges. Most of the unlocks are worth it.
3. All of the syringe items except the yellow one are good.
4. Anything that's a damage-down is usually bad.
5. Prioritize devil rooms over angel rooms.
6. Curse rooms are a good investment if you have decent HP (they're the spiked door rooms).
7. Remember: When you get past Mom, all damage is dealts in full-hearts rather than half-hearts.
8. Don't die, unless you're Lazarus.
9. There are 2 secret characters. Only one has an easy unlock.
You have my skype, and I'm the best Isaac player on the site. I'll answer almost any question you put to me, if I have the time.
Stats"You've been cruel, so don't blame me for being merciless."
[22:33:48] Kazuhiro Hayate : Ask Kozai
[12:21:08] Shadowfax <3 : Dont listen to kozai
[21:08:32] Akane Tokiyama : Kozai makes lit ass jutsu